Bridge to Transplant with Durable Left Ventricular Assist Device is Associated with Primary Graft Dysfunction Following Heart Transplantation: A Report from the International Consortium on Primary Graft Dysfunction

PurposeThe International Consortium on Primary Graft Dysfunction is a multicenter, prospective observational study that has collected data over 2700 HT recipients to identify clinical risk factors for PGD in the contemporary era. The objective of this was determine whether BTT with LVAD associated and, if so, high-risk features recipients.MethodsWe from 10 participating sites Europe, United States (US), and Canada including donor recipient demographics, pre- post-HT hemodynamics, type duration durable support prior HT. primary outcome ISHLT defined severe PGD. Rates were compared between medically managed recipients. Univariate multivariate logistic regression performed characteristics an increased population.ResultsData 2763 consortium included, 837 BTT. seen 215 (7.8%). incidence significantly higher as those who (13.6% v. 6.3%, p<0.001). Using only recipients, univariate identified age, geographic location transplant, dialysis HT, dilated cardiomyopathy, CVP/PCWP ratio significant Results multivariable model are shown Table, where remained significant.ConclusionBTT High-risk include pre-transplant renal failure, RV dysfunction quantified by ratio, within States, non-ischemic cardiomyopathy. We population. Data significant.